I can not launch K-Meleon pointing to any specific profile folder.
How to reproduce the problem:
1. Install latest stable portable version (v75.1 today)
2. Copy its "Profiles\llciq0gk.default" folder (profile folder, containing "prefs.js") into any other location (let say to D:\tmp\KM\p)
3. Try to launch browser with this command like:
".\k-meleon.exe -profilesDir D:\tmp\KM\p"
Here is the thread with more details on the problem -
Using different profiles.